Genetic problems in schizophrenia

  There are many misconceptions among the general population about the genetic aspects of schizophrenia. For example, the relationship between the onset of schizophrenia and heredity. One consultant asked a question like this: My mother is 53 years old, and when she gave birth to me at the age of 9 months, she had a psychotic disorder due to stimulation. Will this disease be passed on to my children from generation to generation because I was not raised on breast milk and my mother got the disease after I was already born? If I have a child now, will it directly affect his health? The cause of schizophrenia is still unknown, but after years of observation and research, it was found that the onset of schizophrenia is closely related to genetics and many other factors: a combination of factors at play.  1. Genetic factors There are many schizophrenic families who ask the question “Is schizophrenia hereditary?  There is a close relationship with heredity. The reasons are as follows: (1) A systematic genealogical survey of schizophrenia patients (3 generations of paternal and maternal lines) found that the prevalence of psychosis among family members of schizophrenia patients was 6.2 times higher than that of the general population. (2) In a survey of 65 families, the prevalence of schizophrenia in children of both parents was 35% to 68% (the prevalence refers to the lifetime probability of the individual in the population). In the normal population, the prevalence was only 0.86%-1%. (3) Investigation of schizophrenic twins revealed that the rate of monozygotic twins (twins developed from fertilization of one egg and two sperms) was 4-6 times higher than that of dizygotic twins (twins developed from fertilization of two eggs and two sperms). (4) Fostering children of schizophrenic patients in the homes of mentally healthy parents since childhood and children of mentally healthy parents in the homes of mentally healthy parents resulted in 19.1% of the total number of foster children with schizophrenia and mental deficiency among children of schizophrenic parents; none of the children of mentally healthy parents suffered from mental illness.  Thus, genetic factors are an important part of the etiology of schizophrenia. The closer the blood relationship, the more prominent the influence of genetic factors.  However, schizophrenia is not directly described as a “genetic disorder” for the following reasons: (1) The mode of inheritance and the method of transmission are still inconclusive. (2) Clinical observations show that a significant number of patients with schizophrenia do not have a family history (no psychiatric patients in the paternal or maternal line for 3 generations).  Personality factors In clinical work, it is noted that 50% to 60% of schizophrenic patients have some special personality traits before they get the disease, such as withdrawn, introverted personality, shyness, suspicious and sensitive, lack of logic in thinking, and good thinking. In psychiatry, some scholars refer to this personality trait as “schizophrenic personality. Based on this phenomenon, it is generally believed that the onset of schizophrenia is somewhat related to premorbid personality traits.  Psychological factors The medical model has changed from a purely biomedical model to an integrated biological, social, and psychological medical model, which has led to a shift in the explanatory model of disease occurrence and a renewed emphasis on social and psychological factors that were previously ignored.  Schizophrenia can be triggered by a variety of psychological factors, such as failed relationships, broken marriages, and frustrated studies and jobs. Survey data show that 44% to 77% of schizophrenia cases have a psychiatric trigger before the onset of schizophrenia. However, most scholars believe that the role of psychiatric factors on the onset of schizophrenia is based on the individual’s psychological ability to cope. In practice, we often see that some people who have encountered great misfortune in their lives and have had extremely difficult paths in life do not suffer from psychosis; on the contrary, some people show emotional depression and even mental disorders in the face of trivial setbacks that almost all people may encounter. While it is true that some patients develop the disease under the effect of definite psychiatric stimuli, it is also true that many schizophrenics do not have definite psychiatric factors before the onset of the disease. It can be seen that mental stimuli only play a triggering role in the development of schizophrenia.  4. Social environmental factors A survey in the United States found that the prevalence of schizophrenia was higher among people living in poverty, in poor economic conditions, and in the lowest social classes living in slums. Similar results were obtained in our survey, that is, the prevalence of schizophrenia was significantly higher among people with low economic levels and no occupation than among people with high economic levels of occupation. In practice, it has also been observed that many schizophrenic patients have unusual social life experiences before the disease, such as being spoiled by their families since childhood, forming lonely and introverted schizophrenic personality traits; some have a tense family atmosphere, divorced parents, and are discriminated against by their stepmother; some leave their families when they do not yet have the ability to live independently, and go far from their parents to settle in the frontier and remote mountainous areas, etc. Due to their poor adaptation to the environment It is also not uncommon for people to suffer from schizophrenia due to maladjustment to the environment.  Therefore, according to the above, if your mother has the genetic quality of the disease, then you also have the genetic quality of the disease. There is no relation to when your mother developed the disease. And the inheritance of this disease does not take place through food. Therefore, there is also no direct relationship with whether you are breastfeeding or not, and the fact that you are currently carrying a child versus your mother not being at the onset of the disease and not breastfeeding does not reduce the risk of the disease. And based on the possible onset factors of schizophrenia, what you need to do is not to worry about the genetic factors, because the genetic factors are already established and cannot be changed. What you can change are the other factors that cause the onset of the disease, such as adjusting your state of mind to keep yourself in a happy state; running a good family environment to keep your children in a harmonious, healthy and safe environment, and developing your children’s abilities to improve their ability to cope with setbacks, which is conducive to their healthy growth.  Finally, I wish you all the best and have a healthy child.