Headache is a common discomfort that probably everyone has experienced in their lifetime. It mainly manifests as full or localized head distension or dull pain, pulsating pain, head heaviness, hat-wearing or strangulation sensation, etc. It may be accompanied by nausea, vomiting, vertigo and visual disturbance. A variety of diseases can cause different kinds of head pain. Head pain can be diagnosed according to the speed of occurrence, location of pain, time of occurrence and duration, degree of pain, nature of pain and accompanying symptoms. What are the headaches that need our attention and timely medical attention? 1.Persistent headache with fever, which often indicates intracranial infection or systemic infection. 2.Headache accompanied by mental symptoms, such as confused speech, confusion, etc. 3.Headache accompanied by twitching of limbs. 4.Headache accompanied by double vision or blurred vision. 5.Recurrent headache in children and adolescents without relief may suggest intracranial vascular abnormalities or occupying lesions. 6.Persistent headache after trauma requires prompt CT examination at the hospital to exclude cerebral hemorrhage. 7.Sudden onset of headache in the elderly. 8.Long-term headache, this time with a change in nature, also requires prompt medical attention. 9.Severe headache, often waking up in pain during sleep, often suggests organic disease. 10.Headache accompanied by nausea, especially jet vomiting, often indicates increased intracranial pressure and requires prompt medical attention. 11.Headache accompanied by a sharp increase in blood pressure suggests the possible existence of hypertensive encephalopathy or malignant hypertension, which requires timely hospitalization for antihypertensive treatment and brain CT examination. 12.When the headache is obviously related to the body position or posture, it may suggest the change of intracranial pressure, and lumbar puncture examination is needed. 13.When the headache is accompanied by numbness or weakness of limbs or speech disorder, it suggests brain hemorrhage, and timely consultation is important.