Clinical research on optimizing comprehensive treatment of colorectal cancer Due to human own reasons, the 20th century showed a significant increase in the incidence of tumors in developed countries, and developing countries gradually followed in the latter half of the century, and tumors became a multi-morbidity and common disease threatening human health. Although all countries in the world try their best to prevent and control such diseases as tumors, the progress is not fast. It is still the main cause of death. Therefore, we should review the mistakes in the past work where? In the last half century, the treatment of tumor has entered the era of comprehensive treatment. Although there has been a good beginning and a good trend to solve the tumor problem, and the cure rate has been improved to some extent, there is still a need for improvement in terms of overall strategy. We have a long way to go and need the cooperation of all parties to achieve a significant reduction in incidence and improvement in cure rate. Fan Enxue, Department of Colorectal and Anorectal Surgery, Second Hospital of Jilin University, China 1 Human understanding of tumor in different ages 1 Tumor has been recorded in ancient England, China, Japan and other countries, and still today. In Japan, tumor is still called “swollen ulcer”. It is a kind of ancient disease and related to modern times, in fact, it is very likely that tumors existed on earth in the era when there were no human beings. According to WHO report, the incidence of cancer in China has been on the rise for the past 500 years. Especially colorectal cancer and others have increased significantly. It is related to lifestyle and diet. 2 The different understanding of tumor in different generations has a significant impact on the diagnosis and treatment. Current research shows that the proto-oncogene controls the growth and development of normal cells. This is the internal cause and is an important factor in tumor development. It is more than a thousand years earlier than the West, and can be understood as the “positive deficiency” in Chinese medicine. At present, clinical medicine is in an era of major changes, and evidence-based medicine, standardized treatment and individualized protocols have become a recognized trend in academic circles. Because tumor is a very heterogeneous disease, not only the clinical manifestations vary, but also the response to treatment is complex and inconsistent. From the current understanding of tumors, it is impossible to cure all tumors by one simple treatment or drug, and there is not much hope from the long-term viewpoint. 3 Treatment is diverse and comprehensive treatment is a principle. Comprehensive treatment is a treatment method that combines several existing treatments in a reasonable and planned way according to the type, nature, disease stage and development trend of malignant tumors. The purpose is to increase the cure rate and improve the quality of life. At present, the cure rate is more than 50%, and the “incurable disease” has become history. 4 Pay attention to rehabilitation and quality of life. The trend of tumor treatment in the new century: 1 Evidence-based medicine, 2 Individualization of treatment, and how clinicians can embed new technologies such as “gene chip” (targeted therapy) in the comprehensive treatment of patients. Only a good combination can improve the quality of life and enhance the efficacy. Internationally: NCCN in the United States issues guidelines twice a year; American Society of Clinical Oncology (ASCO) treatment specifications. In our department, during the clinical research and treatment work from 1999 to 2007, under the guidance of Yu Baoming (International Multicenter Treatment of Rectal Cancer Collaborative Group Project and Shanghai Key Development Project) and the personal leadership of Director Fang Xuedong, we combined a total of 2305 patients from the Second Hospital of Jilin University, the Third Hospital, Ji’an City Hospital, Tonghua County Hospital and Shanghai Ruijin Hospital of the Second Medical University in Shanghai, trying to find the treatment of colon The latest surgeries include TME + lymph node dissection at the root of the tethered vessels or lymph node dissection at the measurement side (stage C 1 or above), local recurrence re-excision; pre- and post-operative chemotherapy is an important part of comprehensive treatment, and so far, fluorine + platinum or topoisomerase inhibitor + calcium folinic acid is the best chemotherapy regimen; radiotherapy is also an important part of comprehensive treatment. Optimizing systemic combination therapy is the best method to treat colorectal cancer, with an efficiency of about 74%. One how to optimize rectal cancer surgery and reduce local recurrence rate is the key to improve five-year survival rate. Rectal total mesenteric resection with root lymph node dissection of the mesenteric vessels and non-rectal total mesenteric resection are used to treat rectal cancer. The local recurrence rate was 6% (82/1367) after total mesorectal resection with root lymph node dissection of the mesenteric vessels and 34% (32/938) after non-rectal total mesorectal resection, and the P