You should not drink alcohol when taking entecavir. Entecavir is a drug for the treatment of hepatitis B, which mainly inhibits the replication of the hepatitis B virus. For hepatitis B patients taking entecavir, alcohol consumption should be prohibited, although a small amount of alcohol does not necessarily affect the antiviral therapeutic effect of entecavir, but the alcohol itself will lead to liver damage, and if long-term alcohol consumption is combined with the presence of chronic hepatitis B, it will lead to a great increase in the risk of cirrhosis of the liver and liver cancer. For patients with chronic hepatitis B, they need to pay attention to rest, eat a light diet, do not drink alcohol, generally low-fat, high-protein diet, you can eat more fresh vegetables and fruits as appropriate. In the course of antiviral treatment, it is necessary to regularly review the relevant indicators to assess the efficacy of antiviral therapy.