Large liver can be caused by infectious factors, but also by poisons or drugs, tumors or cysts, cholestasis, hepatic stasis and other factors, it is recommended to consult the doctor in time. 1. Infectious factors: including various viruses, bacteria, chlamydia, spirochetes, fungi, parasites and other infections, common diseases include viral hepatitis, bacterial liver abscess, liver tuberculosis, hepatic syphilis, amebic liver abscess, Chinese testicular schistosomiasis and so on. 2. Poison or drug factors: such as heavy metals, carbon tetrachloride, chloroform, ethanol, phenol and other poisons, or azathioprine, methotrexate, phenytoin sodium, phenobarbital, rifampicin and other drugs triggered by side effects. 3. Tumors or cysts: such as hepatoblastoma, hepatic hemangiosarcoma, hepatic cavernous hemangioma, primary hepatocellular carcinoma, secondary hepatocellular carcinoma, polycystic liver, hepatic cysts, etc., which may be accompanied by abdominal distension, abdominal pain, emaciation, jaundice, dyspepsia, malaise and other diseases. 4. Cholestasis: it can be caused by gallbladder stones, common bile duct stones, cholangiocarcinoma and other diseases, including intrahepatic cholestasis and extrahepatic cholestasis. 5. Hepatic stasis: it can be caused by hepatic vein obstruction, congestive heart failure and other factors, and the patient can also be accompanied by abdominal distension, abdominal pain, ascites, nausea, vomiting, discomfort in the right upper abdomen and other symptoms. Patients with symptoms of large liver, persistent unrelieved or also accompanied by other discomforts, should consult a doctor in a timely manner, under the guidance of the doctor to identify the cause of the disease and carry out treatment, do not blindly judge on their own, in order to avoid delaying the condition.