Androgen supplementation is very important in the treatment of patients with hypogonadism due to serum testosterone deficiency. We should not forget that there are also these daily monitoring follow-up plans along with the medication. 1.General check-up: assess the efficacy and side effects of the drugs in the 3rd and 6th month after starting the treatment, and if stable, once a year thereafter; check the drug component-specific side effects. 2.Testosterone concentration: according to the reference value of each hospital (laboratory), adjust the drug dose to maintain the serum testosterone concentration at moderately normal level. 3.Rectal examination: review 3-6 months after the start of treatment, and once a year thereafter; if prostate nodules are found, treatment should be stopped. 4. PSA concentration: review 3-6 months after the start of treatment and once a year thereafter; if PSA increases >1.4 ng/ml in 1 year or the rate of increase >0.4 ng/ml/year, stop treatment and evaluate further. 5.Lower urinary tract symptoms (urinary frequency and urgency, painful urination, etc.): If International Prostate Symptom Score IPSS>19, stop treatment and evaluate further. 6. Erythrocyte pressure: review 3-6 months after the start of treatment and once a year thereafter; if Erythrocyte pressure > 54%, stop treatment and evaluate further. If it is elevated and then reduced to normal, treatment can be restarted from a small dose. 7.Sleep apnea: assess snoring, daytime sleepiness and other symptoms. 8.Bone density: check isotope bone scan if there is minor post-traumatic fracture, osteoporosis, shortening of height, etc. and review every 1-2 years.