Psoriasis is a common and persistent disease, also known as psoriasis, of which nail psoriasis is one, and the main method of treatment can be by calcipotriol, an analog of vitamin D active metabolite, osteotriol. As a new antipsoriatic drug, calcipotriol has been shown to be an intensive modulator of keratinocyte differentiation and proliferation, reducing the amount of epidermal IL-6 and the cell count of activated epidermal T cells in psoriasis patients. Although psoriasis is hereditary, it is not necessary to have a genetic predisposition to develop the disease. The onset of this disease also has a strong relationship with the living environment, so it is important to pay attention to multiple factors in daily life to prevent the occurrence of nail psoriasis.