The most important guideline for the treatment of hepatitis B is the antiviral treatment, and currently for the antiviral treatment, you need to choose the right time. If liver function is abnormal, transaminases are greater than twice the upper limit of normal, HBV-DNA is greater than 10^5copies/ml, and the five indicators of hepatitis B are major triplets, antiviral treatment is required, and the preferred drug is oral entecavir or tenofovir for treatment, with a treatment course of at least four years, if not longer. If it is a minor triplet, the virus is greater than 10^4copies/ml and requires antiviral therapy. In the case of cirrhosis, lifelong medication is required. During the course of treatment, attention needs to be paid to monitoring changes in liver function, hepatitis B DNA, and quantitative hepatitis B five indicators.