Knee strain can be treated and relieved by oral medications, commonly used mainly to support symptomatic medications, there are the following: i. Calcium and vitamin D3, can promote bone metabolism, promote bone mineralization, to avoid bone degeneration due to strain and produce osteoarthritis. Second, anti-inflammatory and analgesic drugs, commonly used non-steroidal anti-inflammatory and analgesic drugs, such as diclofenac, celecoxib, can effectively relieve local inflammation, reduce the pain caused by strain and the symptoms of dysfunction. Third, drugs that nourish joint cartilage, such as glucosamine sulfate, can prevent excessive strain on joint cartilage, which can cause damage and wear of cartilage and eventually affect the function of the knee joint.