Fibroids do not cause melasma. Melasma is often associated with endocrine disorders, but it is not related to the presence of fibroids and is mostly a more persistent skin change that is dermatologic in nature. Uterine fibroids often have a genetic component and are directly related to estrogen levels in the body. They may cause the uterus to increase in size to varying degrees, causing increased menstrual flow, or prolonged menstrual cycles and periods, and may lead to severe anemia or symptoms of peripheral compression, but they do not lead to chloasma. Melasma is caused by pigmentation of the female face and is not associated with uterine fibroids, which do not cause pigmentation and may or may not be present with or without melasma with or without uterine fibroids. The etiology of melasma is unclear, and the presence of genetic predisposition, sun exposure (ultraviolet radiation), and changes in sex hormone levels may be important factors in its development. Melasma is a skin disorder and patients are advised to consult a dermatologist. The first treatment is sun protection, then pay attention to stress reduction and prevention of anxiety. Some can take medication to help control it, and some can apply medication externally to alleviate the symptoms, including preparations of tretinoin, levitraviral vitamin C, glutathione, lignin peroxidase, aminocycline and other medications, and the specific medications need to be followed by the doctor’s instructions.