A white globule ratio of 1.2 is abnormal and is a mild decrease in the white globule ratio. The ratio of albumin to globulin is the ratio of the concentration of albumin to the concentration of globulin in the plasma, and under normal circumstances the ratio is 1.5-2.5, so an albumin-to-globulin ratio of 1.2 is a mild decrease and is abnormal. A mild decrease in the albumin ratio can be seen for two reasons, the first reason, a decrease in albumin concentration: a decrease in albumin concentration can be seen in patients with chronic liver disease and patients with nephrotic syndrome, as well as long-term fever, infection, wasting disease and malignant neoplastic disease, all of which can result in a decrease in albumin concentration, leading to a decrease in the albumin ratio. The second cause, increased globulin concentration, such as various autoimmune diseases, most commonly including patients with rheumatoid arthritis, systemic lupus erythematosus, and multiple myeloma, can also result in a decrease in the white globulin ratio due to increased globulin concentration.