The causes of uremia are mainly divided into primary factors, secondary factors and hereditary factors. 1. Primary factors: The primary factors leading to uremia mainly include primary glomerulonephritis, primary nephrotic syndrome and other diseases. 2. Secondary factors: Most of the other systemic diseases lead to kidney damage, and eventually progress to uremia, common secondary kidney disease mainly include diabetic nephropathy, hypertensive nephropathy, benign small artery nephrosclerosis, lupus nephritis, anaphylactic purpura nephritis, hepatitis B-related nephritis and so on. 3. Hereditary factors: hereditary factors can also lead to kidney damage, and eventually progress to uremia, common hereditary factors are polycystic kidney, Alport syndrome, hereditary nephritis, and so on. It is recommended that patients with uremia consult a doctor in a timely manner to identify the cause and follow the doctor’s instructions for standardized diagnosis and treatment.