Increased cortisol, also known as Cushing’s syndrome, can cause hypokalemia. Cushing’s syndrome can cause hypokalemia, the main reason is that glucocorticoids are over-secreted, with a small amount of salocorticoid effect, which can preserve sodium and excrete potassium, the body’s total sodium increases, blood volume expands, blood pressure rises and lower limb edema, and the urinary potassium excretion increases, resulting in hypokalemia and hyperuricemia. The etiology of Cushing’s syndrome is mostly seen in adrenal adenoma, adrenal hyperplasia, Cushing’s disease, etc. Among them, Cushing’s disease is due to excessive secretion of adrenocorticotropic hormone from the pituitary gland, resulting in increased secretion of cortisol, and some of the patients will be diagnosed with hypokalemia. It is recommended that patients with increased cortisol should go to regular hospitals in time and receive standardized treatment after completing relevant examinations under the guidance of doctors, so as to avoid delaying the condition.