It is often said that growth hormone promotes bone age growth, but this is clearly a misconception, and in 2007, leading experts from major global pediatric endocrine societies in the United States, Europe, and Asia Pacific reached a consensus at a meeting in Mexico that normal doses of growth hormone do not promote bone age growth or sexual development. The reason why some people have this opinion is mainly due to a one-sided understanding. Growth hormone is more often used in children with growth hormone deficiency, and in such children, the bone age is often low. After applying growth hormone to make the growth hormone basically normal, the lagging bone age has a tendency to approach the normal bone age, which is easily mistaken as promoting bone age growth, and there are many children applying growth hormone who have already entered puberty, and the rapid bone age growth in puberty is also easily mistaken as being caused by growth hormone. This is because it is easy to think of any problems during the medication period in terms of drug effects. There is enough evidence to show that boys can achieve almost no growth in bone age after using aromatase inhibitors (because they are not suitable for girls and tend to cause boyishness) so that androgens cannot be converted to estrogens (because they have not been officially approved for the treatment of precocious puberty, they are currently used less clinically and mainly for research), but the amount of aromatase inhibitors is not as high as gonadotropin-releasing hormone analogs ( GnRHa), which inhibits growth hormone secretion, and inhibits growth hormone receptor sensitivity. This suggests that bone growth is mainly related to estrogen (which is also present in boys). Besides, growth hormone is often combined with gonadotropin-releasing hormone analog (GnRHa) to treat true precocious puberty, and if it would significantly promote bone age growth, it would not be used for precocious puberty treatment. Zhao Dongmei of the Children’s Health Care Institute of Jinan Children’s Hospital and patients with gigantism, that is, patients with increased secretion of growth hormone, generally do not have precocious puberty or premature closure of bone age, and if growth hormone promotes bone age growth, patients with gigantism will not become giants. If growth hormone promotes the growth of bone age, it cannot be used to increase lifetime height, so will the FDA approve its use to increase lifetime height? Would there still be so many people spending so much money on long-term use?