Selenium deficiency in the elderly may lead to diseases such as Creutzfeldt-Jakob disease and macrosomia, which may cause symptoms such as dyspnea and muscle atrophy. 1. Creutzfeldt-Jakob disease: usually acute Creutzfeldt-Jakob disease patients often manifested as acute cardiac insufficiency, some patients can also appear in the winter, dyspnea, chest tightness, nausea, vomiting and other symptoms, the serious cases can also appear coughing pink foamy sputum, loss of consciousness, fainting, etc., can also occur serious arrhythmia, shock and so on. Subacute Creutzfeldt-Jakob disease patients are mostly manifested as loss of appetite, cough, shortness of breath, chronic Creutzfeldt-Jakob disease can also be manifested as palpitations, shortness of breath and so on. 2. Large bone joint disease: most common in children and adolescents, the elderly also have morbidity. Usually, patients with mild disease will often appear in the joints of the limbs, thickening, deformation, movement disorders, pain and other symptoms, and in severe cases, short limb deformity, short stature deformity, short fingers, etc., and some patients may also lose their ability to work completely. It is suggested that the above symptoms in the elderly may be related to selenium deficiency, patients need to clarify the cause of the disease in time and take targeted treatment.