Headache in leukemia patients may be related to central nervous system leukemia, intracranial hemorrhage, anemia and so on. 1. Central nervous system leukemia: leukocytes easily infiltrate the intracranial area, which can cause central nervous system leukemia, causing cerebral edema, resulting in increased intracranial pressure and causing obvious headaches. 2. Intracranial hemorrhage: leukemia is prone to hemorrhage, and intracranial hemorrhage may also occur, resulting in headache and vomiting. 3. Anemia: leukemia will have the obstacle of red blood cell production, so it causes anemia. And the condition of anemia will cause the patient to suffer from lack of oxygen in the brain, thus headache and so on. Leukemia headache may also be related to other causes such as intracranial infection, etc. It is recommended to go to the hospital in time.