Generalized eczema is a relatively common skin disease, generalized eczema is not a precursor of any disease, but may be related to the body’s immune function abnormalities, but also may be related to diabetes, hyperthyroidism, chronic infections and other diseases. Eczema is due to a variety of internal and external factors to form a chronic inflammation, is a relatively common type of skin disease, the lesion site can be limited, can also be generalized attack. From the internal factors, the body’s immune function is abnormal when the body’s Th2 cell activation, the number of eosinophils will be significantly higher, patients with eczema or lead to eczema recurrence of the chances of a significant increase. Diabetes mellitus, hyperthyroidism and other diseases will affect the level of hormone secretion in the body, which may lead to itchy skin, which is also an important factor in inducing generalized eczema. For some chronic infectious lesions, the same is the cause of eczema systemic flare-ups, such as chronic gastritis, chronic cholecystitis, chronic inflammation of the urinary tract and so on. From the perspective of external factors, drugs, food, environmental factors and sun exposure are all triggering factors for eczema. It is recommended that patients go to the hospital in a timely manner, after clarifying the cause of the disease, standardized treatment under the guidance of the doctor.