Itchy penile skin at night, you should choose the medicine according to the cause of the disease, if it is pubic lice disease, you can use sulfur ointment, benzyl benzoate emulsion; allergic factors can be used externally with glycerine lotion, hydrocortisone cream; if it is eczema, you can use boric acid solution, etc.; fungal infection caused by jock itch can be used Clotrimazole cream and so on. 1. pubic lice disease: itching caused by pubic lice biting the local skin, you can use topical sulfur ointment, benzyl benzoate emulsion, at the same time, remove pubic hair, underwear hot water ironing. 2. Allergic factors: such as contact dermatitis rash and other allergic causes, itching of the penile skin at night can be used externally glycerine lotion, hydrocortisone cream. 3. Eczema: Eczema caused by internal and external stimuli can also cause penile skin itching at night. You can use boric acid solution, zinc oxide ointment and other medications. 4. Fungal infection: fungal infection caused by ringworm can also cause itchy penis skin at night, you can use clotrimazole cream, terbinafine cream and other antifungal drugs. Itchy penis skin at night, there may be other reasons, you need to go to the hospital for examination, clear cause of treatment as prescribed by the doctor, the drug should be applied under the guidance of the doctor.