Numbness of hands and feet in diabetes is not necessarily a manifestation of the middle and late stages, but mostly a manifestation of poor long-term control of blood glucose. When diabetic patients with numbness of hands and feet should be alert to diabetic peripheral neuropathy, due to the long duration of diabetes, long-term poor glycemic control, the complications of diabetic peripheral neuropathy, which can be manifested as numbness of the hands and feet, pain, fatigue, but also sensory anomalies, sensory allergies, hyperalgesia, and muscular atrophy and other manifestations. Diabetic peripheral neuropathy should strictly control blood glucose, through drugs, diet, exercise to control blood glucose to the ideal level; can apply methylcobalamin and other nutritive nerve drugs to improve the numbness of hands and feet symptoms. Diabetic patients should actively control blood sugar to delay or inhibit the occurrence of diabetic complications. Numbness of hands and feet in diabetes should be timely to the hospital, under the guidance of the doctor’s treatment.