Sertraline can cure OCD. The first-line recommended drugs in clinical practice for OCD are sertraline, fluoxetine, fluvoxamine, and paroxetine. Their main mechanism of action is to improve obsessive thoughts and compulsive symptoms by improving the level of 5-hydroxytryptamine in the brain. The clinical treatment of OCD can be chosen from medication, psychotherapy and physical therapy. Medications such as the first-line recommended 5-hydroxytryptamine reuptake inhibitors mentioned above. When its treatment is not effective, the second-line drug clomipramine can be chosen. Psychotherapy is based on cognitive-behavioral therapy, which can be used to improve patients’ irrational cognition and help them improve their symptoms by using exposure prevention methods. And physical therapy can be used in the clinical multi-parameter biofeedback treatment method, which can achieve good therapeutic results. Therefore, in clinical practice, OCD is often psychotherapy, physiotherapy, and medication, and the combined treatment can achieve more good therapeutic effects.