When complications of infection occur in preterm infants, anti-infective treatment, symptomatic treatment and targeted management are required. Due to the low immunity of preterm infants, immature immune function, immature skin barrier function, insufficient antibodies from the mother and other factors will lead to the emergence of infections, including infectious pneumonia, sepsis and enteritis, etc. At this time, the first need for anti-infective treatment, the use of antibiotics such as cefazoxime and other antibiotics, the symptoms are more serious need to be based on the results of the sputum culture of the choice of drugs. In addition, if the infection is accompanied by respiratory distress and other abnormalities, it is also necessary to administer oxygen and other symptomatic treatment to prevent the life of the newborn from being threatened. If the 26-week-old neonate develops infections and other complications, it is important to choose the appropriate treatment under the guidance of the doctor to promote the health of the neonate’s life. In the future, it is necessary to regularly follow up the neurodevelopment, including physical development and other conditions, and strive to have problems detected and dealt with at an early stage.