The difference between non-invasive upgraded version and amniocentesis is mainly the examination method, the chance of infection and the examination cost, which need to be analyzed specifically. 1. Mode of examination: non-invasive refers to the examination by collecting the pregnant woman’s venous blood and extracting fetal DNA. Amniocentesis refers to the ultrasound guidance, the puncture needle through the pregnant woman’s uterine wall into the amniotic cavity, and then extract the amniotic fluid to test. 2. Chance of infection: The non-invasive upgrade version is virtually non-traumatic to the pregnant woman and has a very low chance of infection. Amniocentesis requires the needle to be inserted into the amniotic fluid cavity, which increases the chance of infection. 3. Examination cost: Compared with amniocentesis, non-invasive upgraded version has a higher examination cost. There are other differences between non-invasive upgraded version and amniocentesis, so it is recommended to choose the most suitable test under the guidance of your doctor.