Nowadays, many diabetic foot patients have either mild or severe renal function problems because some of them have similar causes, such as capillary lesions in both lower limbs and kidneys, and thickening of the vascular basement membrane, leading to abnormal microcirculation, which causes tissue lower limb and kidney lesions. For such patients, treatment definitely needs to take into account each aspect to be effective. I had a patient with both diabetic foot and diabetic nephropathy, grade 3 nephropathy, and regular peritoneal dialysis. They were seen in a tertiary care hospital in Nanjing, and the doctor considered that his condition should be treated for the nephropathy first, and then for the foot disease when it was almost under control. According to the patient and his family, the toe ulcer was very small at first, but the whole toe became black and necrotic in a few days there, and the patient was in great pain. They felt that this was not the way to go on, so they were transferred to a local hospital that was stronger in treating diabetic foot. When they got there, the doctor recommended amputation. He was still young, and it was hard to imagine what life would be like after the amputation. But what could he do without surgery? Later, they were referred to our diabetic foot specialist through referral. So, how to treat patients with diabetic foot combined with diabetic nephropathy like this? First of all, this condition is definitely treatable. Patients with diabetic kidney dysfunction definitely need to receive corresponding treatment, and they should take medication and dialysis if they need it. But it must be remembered that diabetic foot and diabetic nephropathy are also mutually influential and mutually restrained, and it is not necessary to control the nephropathy in order to cure the foot disease. As mentioned above, they both have the same etiology, and treatment can be two-pronged, improving microcirculation in both the foot and the kidney. One more, is the treatment of diabetic foot. Many people may not know the characteristics of diabetic foot. For example, this patient started with a small injury, and in a few days the whole toe will be completely black. In severe cases, the whole foot is involved, and it develops really fast. For patients like this, our plan is to give the patient normal dialysis and also to debride the wound to clean up the infection and necrotic inflammatory tissue, so that it is possible to control the infection upstream, and only when the wound is cleaned up is it possible to seal it normally and the diabetic foot will be cured. Therefore, if you are in the hospital during the treatment of the focus of treatment is kidney disease, foot disease without debridement, we should be alert, need to change the treatment plan, otherwise the mutual influence of both will become more and more serious.