Post-operative recurrence of colon cancer can be treated by re-operation, drug treatment and radiotherapy. 1. Surgery: For patients with postoperative recurrence of colon cancer, if the cancer cells have not metastasized and the patient’s body allows it, radical resection of colon such as right hemicolectomy, transverse colonic resection, left hemicolectomy and sigmoidectomy can be taken according to the site of colon cancer. 2. Drug treatment: if patients’ colon cancer recurs after surgery, they need to follow the doctor’s instruction to use fluorouracil, oxaliplatin and other chemotherapeutic drugs. In addition, some patients can use targeted drugs such as bevacizumab and cetuximab under the guidance of doctors. 3. Radiation therapy: patients with recurrence of colon cancer after surgery need to take radiation therapy to kill cancer cells. It is suggested that patients need to consult doctor in time if there is recurrence of colon cancer after surgery, and doctor will choose appropriate measures to treat the patient’s condition.