The causes of moderate premature ejaculation are more, mostly considered to be related to psychological, hormonal, prostatitis, genetic, erectile dysfunction and other factors. 1. Psychological factors: usually patients have depression, anxiety, tension and other negative emotions, which may induce or aggravate premature ejaculation, and premature ejaculation will also have a certain impact on the patient’s psychology. 2. Hormonal factors: Clinical studies have shown that secondary premature ejaculation is related to the level of thyroid hormones, and some patients with hyperthyroidism will have secondary premature ejaculation, the mechanism is still unclear. 3. Prostatitis: some patients with chronic prostatitis have premature ejaculation, and clinical data show that secondary premature ejaculation often occurs in patients with prostate inflammation. 4. Genetic factors: premature ejaculation has a certain genetic predisposition, clinical studies have shown that the dopamine transporter protein gene tandem has a certain link with the regulation of vaginal ejaculatory latency, and men with tandem duplicate genes can transcribe more transporter proteins, which can lead to a decrease in the downstream synaptic dopamine, which has a bearing on the emergence of premature ejaculation symptoms. 5. Erectile dysfunction: usually erectile dysfunction may coexist with premature ejaculation, and some patients will confuse the two concepts with each other, in order to prevent the failure of erection, rapid ejaculation, which will aggravate the symptoms of premature ejaculation. It is recommended that patients with moderate premature ejaculation identify the cause of their condition in a timely manner, and then under the guidance of a doctor to carry out targeted treatment according to the cause of the condition.