Suitable medicines for constipation that are taken for a long time include Lactulose, Polyethylene Glycol Electrolyte Bulk and other medicines. Constipation is a common digestive system disease with difficulty in defecation as the main symptom, suitable for long time to take the treatment of drugs such as lactulose, polyethylene glycol electrolyte bulk and so on. Lactulose can regulate the microecological status of intestinal flora, reduce blood ammonia and diarrhea, the use of the initial period of bloating and other adverse reactions, allergies, galactosemia, intestinal obstruction and other conditions prohibited. Polyethylene glycol electrolyte bulk is a pure osmotic laxative that does not cause an imbalance of acid-base balance in the body, with common adverse reactions such as nausea, feeling of fullness and bloating, and is contraindicated in cases of allergy. Constipation can be long to eat the drug should be in the physician examination according to the individual situation to give guidance, not to self-medication.