Proteinuria and hypertension often indicate that the filtration barrier of the kidney is impaired, which may be seen in diabetic nephropathy, hypertensive nephropathy, nephrotic syndrome and other related diseases. 1. Diabetic nephropathy: long-term glucose metabolism disorder can lead to glomerular hyperperfusion, high transmembrane pressure and high filtration, which causes glomerular volume increase and capillary surface area increase, leading to elevated glomerular blood flow and capillary pressure and proteinuria production. Therefore, it can lead to proteinuria and hypertension. 2. Hypertensive nephropathy: long-term high blood pressure will lead to kidney damage, glomerulosclerosis, resulting in impaired glomerular filtration function, which can cause small molecular weight protein exudation, leading to the occurrence of urinary protein. 3. Nephrotic syndrome: impaired glomerular filtration membrane barrier in patients with nephrotic syndrome can easily lead to an increase in protein content in the original urine, and when the increase significantly exceeds the amount of proximal tubular reabsorption, a large amount of proteinuria will be formed. In addition, the impaired glomerular filtration membrane barrier can easily cause water and sodium retention, which can lead to the occurrence of hypertension. If proteinuria and hypertension are found, it is recommended to consult a doctor for further examination and standardized treatment as prescribed by the doctor.