Closed-cell pimples are a type of acne, and it is recommended to remove them completely through general treatment, topical medication or systematic application of medication, as well as complementary therapies. 1. General treatment: acne is associated with a large increase in the secretion of sebaceous glands in hair follicles, initially conical papules consistent with hair follicles, which can form whiteheads. At this time, it is necessary to pay attention to the removal of oil from the surface of the skin, timely control of oil and moisturizing, and the use of mild moisturizing emulsions. 2. Topical medication: Topical retinoids such as isotretinoin, benzoyl peroxide, selenium disulfide lotion or azelaic acid can be used to promote the dissolution of acne. 3. Systemic medication: choose antibiotics, isotretinoin and other drugs to fight inflammation and inhibit acne production. 4. Adjunctive treatment: acne removal under sterile conditions, using acne squeezer to squeeze out the acne. For skin lesions such as closed mouth acne on both cheeks, it is recommended to consult a doctor in a timely manner and standardize the use of medication under the guidance of the doctor.