Itching all over the body while sleeping in the middle of the night requires careful observation of the skin appearance. If the skin surface is normal without any abnormality, it is considered that the pruritus is caused by allergic factors. You can use compound chlorhexidine acetate spray for external application, which can relieve itching, together with oral cetirizine tablets, which can effectively eliminate itching and improve your symptoms. If the whole body appears to have the wind ball-like change, protruding from the skin, flesh-colored, white or pink, it is considered to be acute urticaria, the degranulation of mast cells caused by the action of allergic factors on mast cells, so that the subcutaneous edema. It is recommended to choose glycerine lotion or zinc oxide cream, you can also choose the external application of chilled mineral water, which can effectively make the urticaria subside and achieve the purpose of removing the itching.