If the patient has elevated amino-terminal natriuretic peptide precursors, the first consideration is that the patient may have heart failure, especially if the patient has dyspnea, shortness of breath, wheezing, and lower limb edema, which are highly considered to be caused by heart failure. It is suggested that the patient should further combine with cardiac ultrasound examination to further clarify the diagnosis. In addition, some patients may have severe infections, tumors or renal insufficiency, which may also lead to elevation of amino-terminal natriuretic peptide precursors, so the specificity of this index is not very high. In addition, it is also age-related, so it is not always clinically significant, and its relative normal value varies from one age group to another.