Sperm abnormality and immunization are possibly related, but there are many causes of sperm abnormality. Other causes include infection, varicocele, environmental factors, genetic factors, drug factors, physical factors, and other factors. 1. Infections: Infections of the reproductive tract and reproductive glands can lead to sperm malformations, such as Mycoplasma and Chlamydia trachomatis infections. 2. Varicocele: Varicocele can cause an increase in the number of immature spermatozoa as well as round-headed spermatozoa, resulting in sperm malformation. 3. Environmental factors: some chemical substances can lead to sperm deformities, mainly including metals and pesticides, the former such as boron, cadmium, chromium, lead, etc., the latter such as phenoxyhydroxy acid pesticides, organomercury pesticides, organophosphorus pesticides and so on. 4. Hereditary factors: men with a high rate of abnormal spermatozoa may have hereditary diseases. 5. Drug factors: long-term application of estrogen, androgens, corticosteroids, etc. can cause low sperm count and high percentage of deformed sperm. 6. Physical factors: such as high temperature, laser, ionization, radiation, etc. can act on testes and epididymis, which can lead to sperm deformities. 7. Other factors: tobacco, alcohol on the number of spermatozoa, mobility, morphology and energy have obvious damage. In addition, the lack of trace elements, amino acids and vitamins can also lead to an increase in malformed spermatozoa. Patients with high sperm deformity rate should go to the hospital in time, and standardize the treatment under the guidance of the doctor.