With the current level of medical technology, there is no way to achieve a complete cure for malignant glioma. There is no obvious boundary between malignant glioma and the surrounding brain tissue, and the tumor grows infiltratively, so there is no way to do total resection, and the tumor will surely recur, and the malignant degree of the tumor will increase every time it recurs, and eventually the patients will die because of the repeated recurrence of the tumor, which destroys the surrounding brain tissues, and results in the exhaustion of the brain function and death. Glioma is not sensitive to radiotherapy and chemotherapy, and there is still no chemotherapy drug that is very sensitive to glioma, and chemotherapy can only slow down the growth of the tumor, but cannot completely stop the recurrence of the tumor. Therefore, the prognosis of glioma patients is quite poor. In the case of grade 4 glioma patients, the average survival time is only about 12-14 months, even after surgery plus radiotherapy, gene therapy, targeted therapy, etc., which is a combination of the most advanced treatments.