When the result of Down’s syndrome screening shows “high risk”, pregnant mothers should not be overly nervous, as this can indicate that the probability of the fetus having Down’s syndrome is higher than 1/270, which does not necessarily mean that the fetus is Down’s child. When there is a high risk or an abnormal mom value, the pregnant mother can choose to have a non-invasive genetic test, but to confirm the diagnosis the pregnant mother has to undergo an amniocentesis to confirm whether the baby is really a Down’s child. The most commonly used technique for prenatal diagnosis is amniocentesis, in which a needle is inserted into the amniotic fluid through the pregnant woman’s abdomen under the guidance of ultrasound, and the amniotic fluid is extracted for chromosomal analysis of fetal cells. Amniocentesis is suitable for pregnant women between 16 and 20 weeks of gestation. Down syndrome, also known as trisomy 21 or Down syndrome, is a chromosomal abnormality that causes 60% of children to be aborted in early fetal life, and those who survive will have intellectual backwardness, peculiar facial features, growth disorders and multiple malformations. When a high risk of Down’s syndrome is detected and the fetus is confirmed to be Down’s syndrome by amniocentesis, the best solution for now is to terminate the pregnancy.