What indicators of breast cancer are the most feared abnormalities are not clear in the clinic, because breast cancer can be manifested as different indicators of abnormalities at different times. The diagnosis of breast cancer needs to be made by combining various examination results and indicators. Firstly, physical examination is needed to diagnose whether there are abnormal signs in the patient’s breasts, followed by imaging examination (breast ultrasound, breast magnetic resonance imaging, etc.), laboratory examination (biochemistry, tumor markers, etc.), and if necessary, pathology examination can be conducted to make a pathology diagnosis. In the early stage of breast cancer, there is usually no change in blood biochemistry, while in the late stage, corresponding index changes can occur, such as elevated alkaline phosphatase indicating bone metastasis. Tumor marker tests can assist in the clinical diagnosis of breast cancer. Tumor markers related to breast cancer include carcinoembryonic antigen, carcinoma antigen 15-3, tissue polypeptide antigen, and so on. Therefore, the diagnosis of breast cancer cannot be based on certain indicators alone, but requires a combination of indicators.