Creatinine 100μmol/L is close to the upper limit of normal or mildly elevated, which may be caused by physiological reasons such as higher muscle content, or eating more meat and exercising more; it may also indicate the presence of pathologic factors such as glomerulonephritis, diabetic nephropathy, hypertensive nephropathy and so on. Creatinine is the metabolic end product of creatine in muscle tissue. Creatinine does not bind with protein in the blood and can freely pass through the glomerulus, which is the most commonly used indicator to indirectly reflect the glomerular filtration function. When the renal parenchyma is damaged and the glomerular filtration rate is reduced to a critical point (when the glomerular filtration rate is reduced to 1/3 of normal), the blood creatinine concentration will rise significantly. Normal male serum creatinine is between 53 and 106 μmol/L, female between 44 and 97 μmoI/L, creatinine 100 μmoI/L belongs to close to the upper limit of normal or mildly elevated. Some patients with elevated creatinine is due to the patient’s own muscle content is higher, or usually eat more meat caused by more exercise, if the routine urine and urinary system ultrasound and other related tests are not abnormal, clear kidney without obvious diseases, this creatinine 100μmol / L has no special meaning, no special treatment. If the creatinine is elevated due to pathological factors, such as glomerulonephritis, diabetic nephropathy, hypertensive nephropathy and so on. At this time, creatinine 100μmol/L may suggest that renal function is impaired, and it is necessary to clarify the cause of the disease and treat for the cause of the disease. If you find that creatinine is elevated, it is recommended to go to regular hospitals in time, and give targeted treatment under the guidance of doctors.