The follicle will be discharged under normal circumstances, but endocrine disorders, endometriosis and other diseases may affect the ovulation function, resulting in the mature follicle can not be discharged normally. 1. Normal situation: the follicles in the ovary start to develop under the effect of hormones, gradually grow and move to the surface of the ovary, and when the follicles are fully mature, they rupture from the ovary and are discharged. 2. Endocrine disorders: endocrine disorders may lead to menstrual disorders, obesity, etc., and also affect ovulation, resulting in the phenomenon of follicles not being discharged even when they are mature. 3. Endometriosis: Most endometriosis patients’ serum may contain anti-ovarian antibodies, which will inhibit ovulation, resulting in the follicle maturing and not being able to be discharged. Severe malnutrition, hyperthyroidism, etc. may affect ovarian function and cause anovulation, patients need to go to the hospital as soon as possible according to the cause of clinical treatment.