Hepatitis B triple sun aminotransferase 300U/L, mostly refers to alanine aminotransferase or glutamic oxalate aminotransferase 300U/L, usually suggests that the condition is serious. The normal range of alanine aminotransferase and glutamic oxalate aminotransferase is 0~40U/L. At this time, the examination found that the aminotransferase reaches 300U/L, which has exceeded the normal range by several times, which mostly suggests that the hepatitis B virus has seriously damaged the liver cells, and it has already resulted in obvious liver function damage. It is necessary to carry out antiviral treatment, and at the same time, it is also necessary to carry out liver-protecting treatment. After treatment, the condition can usually be effectively controlled to avoid further damage to the liver. During the treatment period, it is recommended that patients regularly review liver function indexes, abdominal ultrasound, hepatitis B virus quantification and other tests to dynamically understand the changes in the condition. If the patient experiences persistent discomfort while taking the medication, it is recommended to consult a doctor in time to complete the relevant examinations, identify the cause of the disease, and provide symptomatic treatment.