The drug name of paracetamol is chlorpheniramine maleate, which is faster than loratadine in terms of rapid anti-itch effect only. Chlorpheniramine maleate and loratadine, as antihistamines, are effective in relieving some allergic diseases such as atopic dermatitis, neurodermatitis, solar dermatitis, urticaria, eczema, pruritus and insect bites, but there are certain differences in their pharmacological effects, therapeutic effects and side effects. 1. Pharmacological effects: Although chlorpheniramine maleate and loratadine are antihistamines, the former is a first-generation non-selective histamine H1 receptor antagonist, while loratadine, as a second-generation antihistamine, can selectively antagonize peripheral H1 receptors and has almost no effect on central H1 receptors. No effect; 2, therapeutic effect: chlorpheniramine maleate is mainly used for skin allergies, also has a certain alleviating effect on allergic rhinitis, and because of the inhibitory effect on the central nervous system, can strengthen the role of narcotic and antidepressant drugs. And loratadine is mainly aimed at relieving the symptoms of allergic rhinitis is more effective, for skin allergies also have a certain relief effect, and longer action time; 3, side effects: both may appear dry mouth, anorexia and other gastrointestinal reactions. However, because chlorpheniramine maleate can pass the blood-brain barrier and has an inhibitory effect on the central nervous system, side effects such as drowsiness, decreased attention span and slower reaction often occur after application. Loratadine, on the other hand, is more selective and has minimal side effects on the central nervous system. Therefore, the clinical use of the drug should be decided according to the severity of the patient’s main symptoms and the needs of work and study. If the allergy causes itching more severely, chlorpheniramine maleate can be applied to relieve itching, but after using it, you should not work at height, drive and other work that requires mental concentration, which may increase the danger.