Numbness of the soles of the feet when running may be caused by physiological reasons such as unsuitable shoes and excessive exercise, or it may be caused by pathological reasons such as sciatic nerve compression and diabetes mellitus. 1. Physiological reasons: if you choose unsuitable shoes when running, it may cause the soft tissues of the foot to be pressurized for a long time, affecting the blood circulation of the whole sole of the foot, resulting in numbness of the soles of the feet; in addition, if you run for too long a time, exceeding the body’s exercise load, it may also lead to local microcirculation disorders, resulting in nerve ischemia and lack of oxygen. 2. Pathological reasons: if the sciatic nerve is stimulated by pressure or excessive pulling, there may be numbness along the sciatic nerve travel area, such as pear-shaped muscle syndrome, lumbar intervertebral disc herniation and other diseases; diabetic patients with poor glycemic control or long duration of the disease, there will be atrophy of the peripheral nerves as well as microvascular pathology, and the symptom may also occur. Running foot numbness symptoms alone sometimes can not accurately determine the cause, but also need to be combined with the characteristics of the medical history, other test results in order to make an accurate judgment, it is recommended that the cause of the disease under the guidance of a doctor.