Waking up in the middle of the night with a sticky mouth may be due to abnormal digestive function, lack of certain vitamins, or oral diseases, etc., need to be analyzed. 1. Digestive abnormalities: If in daily life often overeating or often eat stimulating food may cause digestive abnormalities, patients are often accompanied by acid reflux, waking up at night with a sticky mouth. 2. Lack of vitamins: If you are picky about what you eat in your life, you may suffer from a lack of vitamins, such as vitamin B12, which may cause acid reflux and lead to a sticky mouth when you wake up in the middle of the night. 3. Oral disease: In addition, there may be because of insufficient oral care, by the oral mucosa infection and other diseases caused by sticky mouth. Waking up in the middle of the night with a sticky mouth and the long term does not get better, there may be other reasons, you need to consult a doctor in a timely manner, under the guidance of the doctor to improve the relevant examination, and take targeted measures to deal with.