Prednisone belongs to the glucocorticoid class of drugs and may cause adverse reactions such as obesity, osteoporosis and peptic ulcer when taken continuously for more than 10 days. Prednisone is a synthetic intermediate-acting preparation with anti-inflammatory, anti-allergic and anti-shock effects, mainly used for the treatment of rheumatoid arthritis, bronchial asthma persistent state, acute leukemia and other diseases. Usually, weight gain occurs after 10 consecutive days of prednisone administration. Patients who continue to take it may gradually develop facial acne, menstrual disorders, osteoporosis, nausea and vomiting, and other hazards. Therefore, patients who apply prednisone to treat their diseases should strictly follow the doctor’s instructions, and after the symptoms are obviously relieved, it is recommended to reduce the drug dose and gradually stop the drug under the guidance of the doctor, which can prevent the occurrence of adverse drug reactions. In addition, it should be noted that patients with diabetes, osteoporosis, cirrhosis, renal dysfunction, and hypothyroidism need to use prednisone with caution, and it is best to consult a doctor before using the drug.