Osteoarthritis is a very common form of chronic arthritis that can develop or worsen with excessive activity. Currently, physicians generally use medications to help patients treat osteoarthritis, which are easy to use and very reliable. In order to help patients choose the right medication, the following is a complete list of medications for osteoarthritis. A. Anti-inflammatory painkillers These drugs can be applied at any time for a short period of time according to the performance of the patient’s joint pain or swelling. Commonly used drugs such as acetaminophen (paracetamol), can be the first choice to improve the symptoms of the drug, the drug has a good effect on pain, less adverse reactions and low cost, the daily dosage should not exceed 3 grams, long-term use of large doses can cause liver and kidney damage. One is diclofenac (fotarine), meloxicam, nabumetone, etodolac, sulforaphane and asimethicin, which have anti-inflammatory, analgesic and antipyretic effects, and have no adverse effect on the synthesis of articular cartilage matrix proteoglycan, and even have a role in promoting synthesis, which is beneficial to the treatment of osteoarthritis, suitable for use. The second is that aspirin, salicylic acid, pau d’arco, indomethacin (anti-inflammatory pain), naproxen and other anti-inflammatory and analgesic effects, but inhibit the synthesis of articular cartilage matrix proteoglycan, is not conducive to the recovery of patients, so it should not be used. If the above-mentioned drugs are not effective or the condition is serious, opioids such as codeine and tramadol can be used for short-term treatment, but there are adverse reactions such as nausea, vomiting, diarrhea, excessive sweating, etc. It is especially important to note that these drugs have a certain degree of tolerance and potential dependence. Second, glucosamine sulfate can be used as a basic therapeutic drug for a long time because it can both anti-inflammatory and pain relief, improve symptoms and protect joint cartilage and delay the development of osteoarthritis of the knee. It has been reported that this drug and its combination with chondroitin sulfate have become popular food supplements in the United States and are available in supermarkets. The therapeutic dosage of this drug is 1500 mg per day. The active ingredient is diacetyl rhubarb acid (also known as diacerein), which has anti-inflammatory and cartilage-protective effects on joints and can be used in combination with glucosamine sulfate at the beginning of treatment or alone. The best recommended dose of this drug for the treatment of osteoarthritis is 100 mg per day, which can significantly improve the patient’s symptoms, with adverse effects seen in transient diarrhea. Vitamin A, C, and E have antioxidant effects on the osteoarthritis process, and vitamin D plays a role in osteoarthritis through bone mineralization and cell differentiation. One researcher treated 29 cases with vitamin E at 600 mg per day (such a high dose is not appropriate for long-term use) for 10 days and found significant pain relief in more than half of the patients. V. Hyaluronic acid preparations are drugs extracted and purified from cockles, which have good effects on improving symptoms, function and quality of life, and are mainly used for osteoarthritis of the knee, when conventional treatment is not effective, or when anti-inflammatory painkillers are not tolerated. Domestic sodium vitreous acid injection and imported sodium hyaluronate injection can both be used for intra-articular viscous supplementation therapy (injection administration) for patients. In comparison, imported drugs have better efficacy, but the treatment cost is higher.