The right big toe refers to the big toe of the right foot. Sudden swelling and pain in the big toe of the right foot may be due to trauma, tendonitis, or gout. Different medications (e.g. NSAIDs, anti-gout medications) can be chosen to treat the condition depending on the cause. 1. Trauma: If the swelling and pain of the big toe is caused by trauma, it is recommended to take oral non-steroidal anti-inflammatory drugs such as aspirin enteric-coated tablets, acetaminophen tablets, ibuprofen extended-release capsules, and so on, for treatment. 2. Tendonitis: mostly caused by overuse of muscles and tendons and repeated pulling, which can lead to sudden swelling and pain of the big toe, oral diclofenac sodium extended-release tablets and celecoxib capsules are recommended to relieve swelling and pain. 3 gout: when the patient gout attack, there will be big toe swelling and pain, it is recommended that patients take colchicine tablets, allopurine tablets, etoricoxib tablets and other drugs for treatment. Sudden swelling and pain in the right thumb may also have other causes, it is recommended that the patient consult a doctor in a timely manner, under the guidance of the doctor’s reasonable use of drugs for the treatment of the cause.