Male patients with lupus nephritis type 4 can have children six months after the disease stabilizes and stops taking medication, while female patients’ pregnancy may lead to worsening or relapse of the disease and is not recommended. Lupus nephritis type 4 is a diffuse segmental and diffuse glomerulopathy, which is an immune disease and requires long-term medication. Lupus nephritis type 4 can have severe clinical manifestations of renal insufficiency, such as the presence of large amounts of proteinuria, edema, and elevated creatinine. After lupus nephritis type 4 in men is stabilized by immunosuppressant treatment, due to the relatively small inhibition of the drug on the gonads, childbearing has been considered after six months of stopping the immunosuppressant. However, if a woman has lupus nephritis type 4, pregnancy will put a huge burden on the kidneys, and immune function disorders will occur during pregnancy, which may lead to lupus flare-ups or exacerbations, and childbearing is not recommended.