Ankylosing spondylitis is a chronic inflammatory disease with a slow onset that occurs in young adults between the ages of 15 and 30. It is thought to be related to genetic, immune and infectious factors. The onset of ankylosing spondylitis is usually characterized by low back pain or stiffness, and in severe cases, spinal deformity and joint ankylosis may occur. The treatment of ankylosing spondylitis can be broadly divided into medication, physical therapy and functional exercise, and the specific type of treatment applied to the patient will vary from person to person. 1, the etiology of ankylosing spondylitis (1) the occurrence of ankylosing spondylitis and genetic factors have a relationship, a survey found that 90% of patients have relatives with ankylosing spondylitis in their family. However, it does not mean that the next generation of patients will definitely develop the disease, so there is no need to worry too much. (2) Low immunity can also trigger ankylosing spondylitis, immunological examination found that patients with ankylosing spondylitis have varying degrees of alterations in immunoglobulin and C-reactive protein. (3) Foreign scholars have found that about 80% of patients with ankylosing spondylitis have Klebsiella pneumoniae in their stools, suggesting that the onset of ankylosing spondylitis is related to Klebsiella pneumoniae infection, and that patients with ankylosing spondylitis usually have a combination of digestive and urinary tract infections. The first thing you need to do is to get a good idea of what you are getting into. In the early stages, patients usually show low back pain, most of them do not have a serious impact on life; ankylosing spondylitis to the middle of the development, mainly manifested as low back, lower limb joint pain is obvious, and in severe cases can obviously feel limited functional activities of the spine. The development of the disease to the advanced stage, the patient’s lumbosacral pain increased, spinal pain is severe, and accompanied by generalized joint pain, spinal ankylosis or hunchback deformity. 3, ankylosing spondylitis medication treatment the cause of this disease is more complex, so the treatment is more diverse. The most important treatment modalities are three, namely drug therapy, physical therapy and functional rehabilitation. The best way to treat this disease is to use a combination of different methods depending on the cause of the disease and the course of the disease, so that the various treatment methods can complement each other in order to achieve the overall advantages of treatment. Patients with ankylosing spondylitis must first obtain the correct examination if they are to be treated symptomatically. In the early diagnosis of ankylosing spondylitis, laboratory tests are required when necessary. Laboratory tests include four main tests: routine tests, biochemical tests, immunological tests and HLA (human leukocyte antigen) antigen tests. For patients with unknown diagnosis, the test data can often provide a reference for diagnosis. 1. Routine tests: Some patients with ankylosing spondylitis may have, orthocytic hypochromic anemia and leukocytosis. Most patients have increased blood sedimentation during the active phase. Routine urinalysis is usually normal, and proteinuria may occur when amyloidosis occurs in the kidneys. 2, biochemical examination: most patients with ankylosing spondylitis have elevated CPK, decreased serum albumin, and increased alpha1 and gamma globulins. 3, immunological examination: a small number of patients may have increased IgG, IgA and IgM, serum complement C3 and C4 are also often shown to be increased, serum rheumatoid factor is negative. The HLA antigen test: currently known to be closely related to ankylosing spondylitis is the HLA-B27 allele, although about 90% of patients with positive HLA-B27 test results, but no diagnostic specificity, because some normal people may also be positive for HLA-B27. HLA-B27 negative patients as long as the clinical manifestations and imaging examination meet the diagnostic criteria, but also can not The possibility of ankylosing spondylitis cannot be ruled out in patients with HLA-B27-negative disease as long as the clinical presentation and imaging meet the diagnostic criteria. In early stage patients with atypical clinical signs and symptoms and questionable imaging results, HLA-B27 testing can also be done to help with early diagnosis. For the treatment of ankylosing spondylitis, it is usually considered that active exercise and physical therapy have some benefit ankylosing spondylitis patients may wish to do some simple medical care exercises when performing self-exercise. (1) bed stretching exercises: when you wake up in the morning, using the supine position, arms up over the head, stretching in both directions to the fingers and toes, stretching satisfaction, relax; stretching the legs, heel down stretch, the back of the foot to the knee direction of flexion, to satisfaction and relax. Can be repeatedly done several times. (2) Knee-thorax exercise: supine position, both feet on the bed board, bend the knee, lift the knee slowly to the chest direction of flexion, hands holding the knee pulled to the chest, to satisfaction, back to the original position of the feet, followed by the other knee to do the above exercise. Repeat 2 to 3 times for each knee. Do the hands holding both knees movement 2 to 3 times, until the stiffness disappears. (3) cat back exercise: lie on your back and kneel like a cat, lower your head and relax as much as possible, while arching your back like an arch, until you are satisfied with the stretching; after returning to the original position, collapse your back, tilt your head and lift your hips, and try to stretch until you are satisfied. Repeat this 5 times. (4) abdominal exercises: the purpose is to stretch the abdominal muscles, improve muscle strength and maintain a straight posture of the trunk. Supine position, bend the knees, feet on the ground, arms at the side of the body, head and shoulders together slowly raised to the hands touching the knees, adhere to 5 seconds, return to the original position, the above action repeated 5 times. Other functional exercise modalities: Although ankylosing spondylitis cannot be completely cured, pain and disease progression can be completely controlled through a combination of medications, chiropractic care, physical therapy, and functional exercise, among which American manipulation and AMCT technology for the release of vertebral joints and muscle ligaments and other tissues is an important technique to improve this problem!