Colchicine can usually be taken with celecoxib. Colchicine and celecoxib can be taken together to treat severe pain during an acute attack of gouty arthritis. Colchicine is used to treat acute attacks of gouty arthritis and to prevent acute attacks of recurrent gouty arthritis. Some patients experience side effects such as abdominal pain, diarrhea, shock and muscle weakness. It is contraindicated for hypomelanosis, and renal and hepatic insufficiency. Precautions: If vomiting, diarrhea and other reactions occur, the dosage should be reduced, and in serious cases, the drug should be stopped immediately. Blood and liver and kidney functions should be checked regularly during the use of the drug. Celecoxib is used to relieve the signs and symptoms of osteoarthritis, to relieve the signs and symptoms of adult rheumatoid arthritis, to treat acute pain in adults, and to relieve the signs and symptoms of ankylosing spondylitis. Adverse reactions such as gastrointestinal bleeding, hepatotoxicity, and hypertension can occur after administration. It is contraindicated in people with severe heart failure, coronary artery bypass graft surgery, and active peptic ulcers. CAUTION: Nonsteroidal anti-inflammatory drugs (NSAIDs), including celecoxib, can cause new-onset hypertension or exacerbate pre-existing hypertension, either of which can lead to an increased incidence of cardiovascular events. When taking colchicine and celecoxib, patients are advised to use them under the advice of a physician to avoid medication risks.