If you feel uncomfortable with your legs at night, there are usually several factors: 1. Common orthopedic diseases, such as lumbar disc herniation, lumbar disc bulge, sciatica, sacroiliac arthritis, etc., can compress the nerves in the legs and cause swelling of the nerve roots that govern the legs, causing uncomfortable legs at night. 2. In the presence of kidney disease caused by immune deficiency, the legs will be swollen at night due to poor reflux in the lower limbs, causing uncomfortable legs. 3, heart disease, such as cardiac insufficiency, will also have swollen lower limbs, poor reflux, or uncomfortable legs due to arteriovenous obstruction. 4, in cerebrovascular disease, there are also clinical symptoms of uncomfortable legs at night.