Myocardial ischemia and hypoxia should first be judged as to what causes it. If it is caused by coronary artery lumen narrowing due to coronary atherosclerosis, it belongs to coronary heart disease. Myocardial ischemia and hypoxia is a pathological manifestation of coronary heart disease, which can appear as clinical manifestations such as chest pain, chest tightness, shortness of breath and dyspnea, and requires timely treatment. Severe myocardial ischemia, hypoxia, and severe lumen stenosis require medication, such as nitrates or beta-blockers, and statins for plaque stabilization, which are the drug of choice for coronary artery disease. If coronary spasm causes myocardial ischemia and hypoxia, it is different from the treatment of coronary artery disease, and calcium antagonists can be preferred for treatment. Therefore, for the treatment of myocardial ischemia and hypoxia, there are various means, and a combination of Chinese and Western medicine can be used. Depending on the degree of severity, the treatment method also differs. If the manifestations and symptoms of myocardial ischemia and hypoxia are found, it is necessary to go to the hospital in time to find a specialist to formulate the correct treatment plan.