Hepatitis B Minor Triple Positive becomes Major Triple Positive, indicating that the virus is activated resulting in an increase in viral load. Further tests such as Hepatitis B DNA test and liver function tests are needed. Follow the doctor’s instructions for drug treatment. 1. Hepatitis B virus DNA test Hepatitis B DNA test is done to find out the increase in the amount of hepatitis B virus. The normal range is negative. If hepatitis B minor triple positive becomes major triple positive, it means that the virus may be activated to increase the replication of the virus, and further liver function and hepatitis B virus DNA tests are needed. If hepatitis B DNA is more than 10^6 and liver function is abnormal, it is recommended to take oral antiviral drugs such as tenofovir disoproxil fumarate tablets to inhibit the replication of hepatitis B virus and slow down the further development of liver fibrosis under the instruction of doctor. 2.Liver function test Liver function test is to feedback whether the liver is damaged and the degree of damage. If Hepatitis B minor tri-positive turns into major tri-positive, it may lead to greater damage to the liver and active viral replication. It is necessary to combine with the results of Hepatitis B DNA and other related results to determine. If the viral load is high and the liver function is obviously high, oral antiviral drugs such as tenofovir disoproxil fumarate tablets and liver protection tablets should be used to protect the liver under the guidance of the doctor. Hepatitis B minor tri-positive to Hepatitis B major tri-positive should be regularly rechecked, and at the same time should actively go to the hospital to check the liver function and Hepatitis B virus DNA and other related tests.