The treatment of herpes simplex stomatitis can be divided into systemic drugs and topical drugs. 1. Systemic medication: if it is the primary type of herpes simplex stomatitis, you can choose acyclovir, famciclovir, the course of treatment for about 8 days; for the recurrent type need to use intermittent therapy, the course of treatment is generally 5 days; frequent recurrence type using continuous inhibitory therapy, need to be taken orally for half a year to one year; for acyclovir-resistant can be chosen to use phosphonate for 2~3 weeks or until cured. 2. Topical medication: keep the mouth clean, use oral gargle solution. Herpetic stomatitis pain is more obvious, sometimes there will be fever, local lymph node pain, sore throat, etc. Therefore, you should consult a doctor in time, under the guidance of a professional doctor to take appropriate treatment to maximize the quality of life. Medications should be used under the direction of a physician.